Inevitably, the universe will end; electrons will no longer spin around nuclei, and everything will stop.
But before that, the Milk Way will be consumed by the blackhole at its core, leaving only void in its wake.
But before that, the sun will swallow Earth as it grows into a red giant and explodes.
But before that, living on Earth will no longer be sustainable; temperatures and sea levels will rise beyond the point of any coping mechanisms.
But before that, you will die; a small tragedy on the scale of things, but a tragedy nonetheless.